Article
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Nature communications - 17 May 2022
Lee Bernard C H, Robinson Philip S, Coorens Tim H H, Yan Helen H N, Olafsson Sigurgeir, Lee-Six Henry, Sanders Mathijs A, Siu Hoi Cheong, Hewinson James, Yue Sarah S K, Tsui Wai Yin, Chan Annie S Y, Chan Anthony K W, Ho Siu Lun, Campbell Peter J, Martincorena Inigo, Buczacki Simon J A, Yuen Siu Tsan, Leung Suet Yi, Stratton Michael R
Abstract excerpt
Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic mutation burdens, information on mutation rates in normal tissues and understanding of the trajectory from normal to cancer cell is limited. Here we whole genome sequence 152 crypts from...
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