Article

A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis

2020-12-29

Abstract excerpt

Lynch syndrome (LS), the most common inherited colorectal cancer (CRC) syndrome, increases the cancer risk in affected individuals. LS is caused by pathogenic germline variants in one of the DNA mismatch repair (MMR) genes, complete inactivation of which causes numerous mutations in affected cells. As CRC is believed to originate in colonic crypts, understanding the intra-crypt dynamics caused by mutational proces...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9378d7e-1475-5d36-9c78-b5cf3fdeb4bd
DOI: 10.1101/2020.12.29.424555

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesisDOI 10.1101/2020.12.29.424555Read

Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure.Semantic proximity Read

Mutational landscape of normal epithelial cells in Lynch Syndrome patients.Semantic proximity Read

Mathematical Modeling of Multiple Pathways in Colorectal Carcinogenesis using Dynamical Systems with Kronecker StructureSemantic proximity Read

Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesisSemantic proximity Read

Modeling of stem cell dynamics in human colonic crypts in silico.Semantic proximity Read

Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesis.Semantic proximity Read

The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts.Semantic proximity Read

Role of heterozygous APC mutation in niche succession and initiation of colorectal cancer--a computational study.Semantic proximity Read

From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and BiologySemantic proximity Read

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixtureSemantic proximity Read

A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments.Semantic proximity Read

Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.Semantic proximity Read