Article

Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysis

2025-04-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Lynch Syndrome (LS) is an autosomal dominant disease characterized by germline heterozygous mutations in DNA mismatch repair (MMR) genes. High-risk LS patients may proceed to colorectal cancer (CRC). However, the drivers or biomarkers of LS benign colon tissue approaching malignant CRC are not completely understood. The similarity and difference between LS-related and nonLS-...

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Literature Corpus work: edeb2964-aa73-5254-a742-75a0e9d6b205
DOI: 10.1101/2025.04.06.647495

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