Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular pathology of Lynch syndrome.

The Journal of pathology - 1 Apr 2020

Cerretelli Guia, Ager Ann, Arends Mark J, Frayling Ian M

Abstract excerpt

Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. It is probably the most common predisposition to cancer, having an estimated prevalence of between 1/100 and 1/180. Resources such as the International Society for Gastrointestinal Hereditary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal and Anal Carcinomas
Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to Endometrial Neoplasms

Share to Genetic factors in colorectal cancer

Share to Genetic Predisposition to Disease

Share to Pathology, Molecular

Source

Identifiers

PMID: 32141610
DOI: 10.1002/path.5422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular pathology of Lynch syndrome.PMID 32141610Read ↗

Lynch syndrome: from detection to treatmentSemantic proximity Read ↗

Lynch syndrome in the 21st century: clinical perspectives.Semantic proximity Read ↗

Current clinical topics of Lynch syndrome.Semantic proximity Read ↗

Review article: Lynch Syndrome—a mechanistic and clinical management updateSemantic proximity Read ↗

Recent Advances in Lynch Syndrome: Diagnosis, Treatment, and Cancer PreventionSemantic proximity Read ↗

Genetics, diagnosis and treatment of Lynch syndrome: Old lessons and current challenges (Review)Semantic proximity Read ↗

Lynch-like Syndrome: Potential Mechanisms and ManagementSemantic proximity Read ↗

Lynch syndrome and colorectal cancer: A review of current perspectives in molecular genetics and clinical strategiesSemantic proximity Read ↗

How Should We Test for Lynch Syndrome? A Review of Current Guidelines and Future StrategiesSemantic proximity Read ↗

Recent advances in Lynch syndromeSemantic proximity Read ↗

Lynch Syndrome: From Carcinogenesis to Prevention InterventionsSemantic proximity Read ↗

A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.