Article
Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.
The Journal of pathology - 1 Oct 2017
Binder Hans, Hopp Lydia, Schweiger Michal R, Hoffmann Steve, Jühling Frank, Kerick Martin, Timmermann Bernd, Siebert Susann, Grimm Christina, Nersisyan Lilit, Arakelyan Arsen, Herberg Maria, Buske Peter, Loeffler-Wirth Henry, Rosolowski Maciej, Engel Christoph, Przybilla Jens, Peifer Martin, Friedrichs Nicolaus, Moeslein Gabriela, Odenthal Margarete, Hussong Michelle, Peters Sophia, Holzapfel Stefanie, Nattermann Jacob, Hueneburg Robert, Schmiegel Wolff, Royer-Pokora Brigitte, Aretz Stefan, Kloth Michael, Kloor Matthias, Buettner Reinhard, Galle Jörg, Loeffler Markus
Abstract excerpt
Colorectal cancer (CRC) arising in Lynch syndrome (LS) comprises tumours with constitutional mutations in DNA mismatch repair genes. There is still a lack of whole-genome and transcriptome studies of LS-CRC to address questions about similarities and differences in mutation and gene expression characteristics between LS-CRC and sporadic CRC, about the molecular heterogeneity of LS-CRC, and about specific...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.