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Article

Molecular analysis of the evolutionary history of endometrial and ovarian carcinoma in Lynch syndrome.

International journal of cancer - 1 Dec 2025

Kauppinen Anni K, Olkinuora Alisa P, Mecklin Jukka-Pekka, Peltomäki Päivi T

Abstract excerpt

Lynch syndrome (LS) is a prevalent cause of hereditary gynecological cancers. DNA mismatch repair (MMR) defects are important players in LS tumorigenesis, but the developmental steps leading to malignancy are incompletely understood. We undertook a deep sequencing approach with a panel of ~1,000 cancer-associated genes to detect somatic changes in retrospective specimens from 33 LS carriers who had developed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40772756
DOI: 10.1002/ijc.70074
PMCID: PMC12496004

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