Article

MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk

2025-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Tissue microenvironment characteristics associated with elevated risk of colorectal cancer (CRC) in Lynch syndrome (LS) are poorly characterized. We applied the multimodal single cell sequencing platform ExCITE-seq to define the colonic cellular composition and transcriptome of LS carriers with and without a history of CRC compared with general population controls. Our analysis revealed widespre...

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Literature Corpus work: cc7766f9-2da1-51f9-b1c5-0f2ce795b3e8
DOI: 10.1101/2025.08.22.671764

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