Article

MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk

2025-08-25

Abstract excerpt

<title>Abstract</title> <p>Tissue microenvironment characteristics associated with elevated risk of colorectal cancer (CRC) in Lynch syndrome (LS) are poorly characterized. We applied the multimodal single cell sequencing platform ExCITE-seq to define the colonic cellular composition and transcriptome of LS carriers with and without a history of CRC compared with general population controls. Our analysis revealed...

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Literature Corpus work: f73c6aaa-fad7-552b-83e1-fb2dfedf597c
DOI: 10.21203/rs.3.rs-7273425/v1

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