Article

Transcriptome-wide association studies at cell state level using single-cell eQTL data

2025-03-18

Abstract excerpt

Transcriptome-wide association studies (TWAS) have been widely used to prioritize relevant genes for diseases. Current methods for TWAS test gene-disease associations at bulk tissue or cell-type-specific pseudobulk level, which do not account for the heterogeneity within cell types. We present TWiST, a statistical method for TWAS analysis at cell state resolution using single-cell expression quantitative trait loc...

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Literature Corpus work: e6e210d3-7f32-5c77-80a9-1b55224a28d3
DOI: 10.1101/2025.03.17.25324128

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