Article

Therapeutic assessment of targeting ASNS combined with L-Asparaginase treatment in solid tumors and investigation of resistance mechanisms

2020-09-09

Abstract excerpt

Asparagine deprivation by L-Asparaginase (L-ASNase) is an effective therapeutic strategy in Acute Lymphoblastic Leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing Asparagine 1 . L-Asparaginase efficacy in solid tumors is limited by dose-related toxicities 2 . Large-scale loss of function genetic in vitro screens identified ASNS as a cancer dependency in several so...

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Literature Corpus work: 199e25d6-75f2-5d2f-b3a3-ce75f5828f69
DOI: 10.1101/2020.09.08.287565

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