Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

doi:10.1200/JCO.2015.64.5812

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Article

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2016

Liu Chengcheng, Yang Wenjian, Devidas Meenakshi, Cheng Cheng, Pei Deqing, Smith Colton, Carroll William L, Raetz Elizabeth A, Bowman W Paul, Larsen Eric C, Maloney Kelly W, Martin Paul L, Mattano Leonard A, Winick Naomi J, Mardis Elaine R, Fulton Robert S, Bhojwani Deepa, Howard Scott C, Jeha Sima, Pui Ching-Hon, Hunger Stephen P, Evans William E, Loh Mignon L, Relling Mary V

Abstract excerpt

PURPOSE: Acute pancreatitis is one of the common causes of asparaginase intolerance. The mechanism is unknown, and genetic predisposition to asparaginase-induced pancreatitis has not been previously identified. METHODS: To determine clinical risk factors for asparaginase-induced pancreatitis, we studied a cohort of 5,185 children and young adults with acute lymphoblastic leukemia, including 117 (2.3%) who were...

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PMID: 27114598
DOI: 10.1200/JCO.2015.64.5812
PMCID: PMC4962704

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CPA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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