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Article

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.

Blood - 2 Jul 2015

Fernandez Christian A, Smith Colton, Yang Wenjian, Mullighan Charles G, Qu Chunxu, Larsen Eric, Bowman W Paul, Liu Chengcheng, Ramsey Laura B, Chang Tamara, Karol Seth E, Loh Mignon L, Raetz Elizabeth A, Winick Naomi J, Hunger Stephen P, Carroll William L, Jeha Sima, Pui Ching-Hon, Evans William E, Devidas Meenakshi, Relling Mary V

Abstract excerpt

Asparaginase is used to treat acute lymphoblastic leukemia (ALL); however, hypersensitivity reactions can lead to suboptimal asparaginase exposure. Our objective was to use a genome-wide approach to identify loci associated with asparaginase hypersensitivity in children with ALL enrolled on St. Jude Children's Research Hospital (SJCRH) protocols Total XIIIA (n = 154), Total XV (n = 498), and Total XVI (n = 271),...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25987655
DOI: 10.1182/blood-2015-02-628800
PMCID: PMC4492197

Genes

NFATC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.PMID 25987655Read ↗

HLA-DRB1*16:02 is associated with PEG-asparaginase hypersensitivity.Semantic proximity Read ↗

HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.Semantic proximity Read ↗

Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity.Semantic proximity Read ↗

HLA Alleles Associated with Asparaginase Hypersensitivity in Childhood ALL: A Report from the DFCI ConsortiumSemantic proximity Read ↗

HLA-DRB1*07:01–HLA-DQA1*02:01–HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemiaSemantic proximity Read ↗

Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.Semantic proximity Read ↗

Pharmacogenetic markers of PEG-asparaginase toxicity in Brazilian pediatric ALL: insights from a multicenter prospective cohort study.Semantic proximity Read ↗

Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.Semantic proximity Read ↗

Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Subgroups of Paediatric Acute Lymphoblastic Leukaemia Might Differ Significantly in Genetic Predisposition to Asparaginase Hypersensitivity.Semantic proximity Read ↗

A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity.Semantic proximity Read ↗

Review of pharmacogenetics studies of L-asparaginase hypersensitivity in acute lymphoblastic leukemia points to variants in the GRIA1 gene.Semantic proximity Read ↗

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