Article
A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity.
Leukemia - 1 Jan 2011
Chen S-H, Yang W, Fan Y, Stocco G, Crews K R, Yang J J, Paugh S W, Pui C-H, Evans W E, Relling M V
Abstract excerpt
Asparaginase is an important component for treatment of childhood acute lymphoblastic leukemia (ALL). The basis for interindividual differences in asparaginase sensitivity remains unclear. To comprehensively identify genetic variants important in the cytotoxicity of asparaginase, we used a genome-wide association approach using the HapMap lymphoblastoid cell lines (87 CEU trio members) and 54 primary ALL leukemic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.