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Article

Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol.

Leukemia - 1 Feb 2017

Wolthers B O, Frandsen T L, Abrahamsson J, Albertsen B K, Helt L R, Heyman M, Jónsson Ó G, Kõrgvee L T, Lund B, Raja R A, Rasmussen K K, Taskinen M, Tulstrup M, Vaitkevičienė G E, Yadav R, Gupta R, Schmiegelow K

Abstract excerpt

Asparaginase (ASP)-associated pancreatitis (AAP) occurs during acute lymphoblastic leukemia treatment. Among 1285 children (1.0-17.9 years) diagnosed during July 2008-December 2014 and treated according to the Nordic/Baltic ALL2008 protocol, 86 (cumulative incidence=6.8%) developed AAP. Seventy-three cases were severe (diagnostic AAP criteria persisting >72 h) and 13 mild. Cases were older than controls (median:...

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Identifiers

PMID: 27451978
DOI: 10.1038/leu.2016.203

Genes

RGS6
ULK2

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