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Therapeutic Assessment of Targeting ASNS Combined with l -Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms

13 Jan 2021

Abstract excerpt

Asparagine deprivation by l -asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine ( Annu. Rev. Biochem. 2006, 75 (1), 629–654). l -Asparaginase efficacy in solid tumors is limited by dose-related toxicities ( OncoTargets and Therapy 2017, pp 1413–1422). Large-scale loss of...

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PMID: 33615182
DOI: 10.1021/acsptsci.0c00196

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