Novel Genetic Risk Factor Identified for L-Asparaginase-Induced Pancreatitis in Pediatric Patients With Cancer.

doi:10.1002/1545-5017.70284

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Article

Novel Genetic Risk Factor Identified for L-Asparaginase-Induced Pancreatitis in Pediatric Patients With Cancer.

Pediatric blood & cancer - 1 Jun 2026

Raack Edward J, Chang Wan-Chun, Cordova-Delgado Miguel, Anderson Spencer J, Trueman Jessica N, Scott Erika N, Loucks Catrina M, Rassekh Shahrad R, Groeneweg Gabriella S S, Higginson Michelle, Li Kathy, Miao Fudan, Yau Derek, Johnston Donna, Ibrahim Mounira, Krajinovic Maja, Tran Thai Hoa, Tewfik Jessica, Bussières Jean-François, Jean-Baptiste Thaïna-Rafi, Lebel Denis, Pecheux Lucie, Gyawali Bina, Guilcher Gregory, Riabowol Gesche, Jong Geert 't, Staub Michelle, Cuvelier Geoff, Felton Kathleen, Khalaj Sara, Rieder Michael, Abuzgaia Awatif, Lewis Tamorah, Ghimire Himal, Nathan Paul, Goralski Kerry, Kulkarni Ketan, Forbrigger Zara, Ross Colin J D, Carleton Bruce C

Abstract excerpt

BACKGROUND: L-asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L-asparaginase, which compromises outcomes. PROCEDURE: Genome-wide analyses were conducted to identify significant associations between single-nucleotide polymorphisms and risk for L-asparaginase-induced...

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PMID: 41889154
DOI: 10.1002/1545-5017.70284

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