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Article

Promoter Proximity Defines Mutation Window for VH and VΚ Genes Rearranged to Different J Genes.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2022

Heltzel Justin H M, Maul Robert W, Yang William, Gearhart Patricia J

Abstract excerpt

Somatic hypermutation induced by activation-induced deaminase (AID) occurs at high densities between the Ig V gene promoter and intronic enhancer, which encompasses DNA encoding the rearranged V gene exon and J intron. It has been proposed that proximity between the promoter and enhancer defines the boundaries of mutation in V regions. However, depending on the J gene used, the distance between the promoter and...

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PMID: 35418469
DOI: 10.4049/jimmunol.2101002
PMCID: PMC9050841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Promoter Proximity Defines Mutation Window for VH and VΚ Genes Rearranged to Different J Genes.PMID 35418469Read ↗

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Semantic proximity Read ↗

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