Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006

Afshar Roshi, Pierce Steven, Bolland Daniel J, Corcoran Anne, Oltz Eugene M

Abstract excerpt

The assembly of Ag receptor genes by V(D)J recombination is regulated by transcriptional promoters and enhancers which control chromatin accessibility at Ig and TCR gene segments to the RAG-1/RAG-2 recombinase complex. Paradoxically, germline deletions of the IgH enhancer (Emu) only modestly redu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Enhancer Elements, Genetic
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

Share to Genes, Immunoglobulin Heavy Chain

Share to Introns

Share to Recombination, Genetic

Share to Regulatory Sequences, Nucleic Acid

Source

Identifiers

PMID: 16456003
DOI: 10.4049/jimmunol.176.4.2439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16456003-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.PMID 16456003Read ↗

Elucidation of IgH intronic enhancer functions via germ-line deletionSemantic proximity Read ↗

A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.Semantic proximity Read ↗

Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.Semantic proximity Read ↗

Contribution of the IGCR1 regulatory element and the 3 <i>’Igh</i> CBEs to Regulation of <i>Igh</i> V(D)J RecombinationSemantic proximity Read ↗

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.Semantic proximity Read ↗

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletionSemantic proximity Read ↗

Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.Semantic proximity Read ↗

Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.Semantic proximity Read ↗

The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.Semantic proximity Read ↗

Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usage.Semantic proximity Read ↗

CTCF-binding elements mediate control of V(D)J recombination.Semantic proximity Read ↗

MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.