Somatic hypermutation of the JC intron is markedly reduced in unrearranged kappa and H alleles and is unevenly distributed in rearranged alleles.

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Article

Somatic hypermutation of the JC intron is markedly reduced in unrearranged kappa and H alleles and is unevenly distributed in rearranged alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 1991

Weber J S, Berry J, Litwin S, Claflin J L

Abstract excerpt

Somatic hypermutation of the Ig genes occurs in rearranged V(D)J and its flanking sequences after Ag stimulation. Even though C regions and unrearranged V segments have been found to lack mutations, it is not known whether the mutational mechanism can be active in unrearranged J segments and thei...

Topics

Alleles
Animals
Base Sequence
Blotting, Southern
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Gene Rearrangement, B-Lymphocyte, Light Chain
Genes, Immunoglobulin
Hybridomas
Immunoglobulin kappa-Chains
Introns
Mice
Molecular Sequence Data
Mutation
Phosphorylcholine
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1901897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1901897-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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