Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.

Nucleic acids research - 17 Apr 2020

Oudinet Chloé, Braikia Fatima-Zohra, Dauba Audrey, Khamlichi Ahmed Amine

Abstract excerpt

Developing B cells undergo V(D)J recombination to generate a vast repertoire of Ig molecules. V(D)J recombination is initiated by the RAG1/RAG2 complex in recombination centres (RCs), where gene segments become accessible to the complex. Whether transcription is the causal factor of accessibility or whether it is a side product of other processes that generate accessibility remains a controversial issue. At the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Helicases
Share to DNA Methylation
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Immunoglobulin Heavy Chains

Share to Nuclear Proteins

Share to Transcription, Genetic

Share to V(D)J Recombination

Source

Open in PubMed Open full text

Identifiers

PMID: 32086526
DOI: 10.1093/nar/gkaa108
PMCID: PMC7144927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recombination may occur in the absence of transcription in the immunoglobulin heavy chain recombination centre.PMID 32086526Read ↗

Elucidation of IgH 3′ region regulatory role during class switch recombination via germline deletionSemantic proximity Read ↗

Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.Semantic proximity Read ↗

Contribution of the IGCR1 regulatory element and the 3 <i>’Igh</i> CBEs to Regulation of <i>Igh</i> V(D)J RecombinationSemantic proximity Read ↗

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cellsSemantic proximity Read ↗

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.Semantic proximity Read ↗

Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.Semantic proximity Read ↗

Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development.Semantic proximity Read ↗

Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination.Semantic proximity Read ↗

The IgH <i>Eμ</i> -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutationSemantic proximity Read ↗

E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.Semantic proximity Read ↗

CTCF-binding elements mediate control of V(D)J recombination.Semantic proximity Read ↗

Genetic recombination is directed away from functional genomic elements in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.