Article
Genetic and epigenetic control of V gene rearrangement frequency.
Advances in experimental medicine and biology - 1 Jan 2009
Feeney Ann J
Abstract excerpt
The antibody repertoire is enormous and reflects the power of combinatorial and junctional diversity to generate avast repertoire with a moderate number of V, D and J gene segments. However, although there are many VH and VK gene segments, the usage of these genes is highly unequal. In this chapter, we summarize our studies elucidating many of the factors that contribute to this unequal rearrangement frequency of...
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