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Article

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation.

Frontiers in immunology - 1 Jan 2023

Martin Ophélie A, Thomas Morgane, Marquet Marie, Bruzeau Charlotte, Garot Armand, Brousse Mylène, Bender Sébastien, Carrion Claire, Choi Jee Eun, Vuong Bao Q, Gearhart Patricia J, Maul Robert W, Le Noir Sandrine, Pinaud Eric

Abstract excerpt

Intoduction: Two scaffold/matrix attachment regions (5'- and 3'-MARsEµ ) flank the intronic core enhancer (cEµ) within the immunoglobulin heavy chain locus (IgH). Besides their conservation in mice and humans, the physiological role of MARsEµ is still unclear and their involvement in somatic hypermutation (SHM) has never been deeply evaluated. Methods: Our study analyzed SHM and its transcriptional control in a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 36865553
DOI: 10.3389/fimmu.2023.1030813
PMCID: PMC9971809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation.PMID 36865553Read ↗

The IgH <i>Eμ</i> -MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutationSemantic proximity Read ↗

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Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.Semantic proximity Read ↗

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.Semantic proximity Read ↗

An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domainSemantic proximity Read ↗

Antisense intergenic transcription precedes Igh D-to-J recombination and is controlled by the intronic enhancer Emu.Semantic proximity Read ↗

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cellsSemantic proximity Read ↗

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment regionSemantic proximity Read ↗

Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.Semantic proximity Read ↗

Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.Semantic proximity Read ↗

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.Semantic proximity Read ↗

A pivotal role for DNase I-sensitive regions 3b and/or 4 in the induction of somatic hypermutation of IgH genes.Semantic proximity Read ↗

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