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Article

Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1991

Weber J S, Berry J, Manser T, Claflin J L

Abstract excerpt

Somatic hypermutation is known to occur in the VJ kappa exon and its flanking sequences, yet little is known about the hypermutation mechanism or its exact target within the rearranged locus. Mutations may occur at the same frequency, spanning a region from the leader intron to 3' of J kappa 5, r...

Topics

Base Sequence
Chromosome Mapping
Gene Rearrangement
Genes, Immunoglobulin
Immunoglobulin Joining Region
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Molecular Sequence Data
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1902859

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1902859-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Position of the rearranged V kappa and its 5' flanking sequences determines the location of somatic mutations in the J kappa locus.PMID 1902859Read ↗

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Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism.Semantic proximity Read ↗

Somatic hypermutation of the JC intron is markedly reduced in unrearranged kappa and H alleles and is unevenly distributed in rearranged alleles.Semantic proximity Read ↗

Promoter Proximity Defines Mutation Window for VH and VΚ Genes Rearranged to Different J Genes.Semantic proximity Read ↗

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes.Semantic proximity Read ↗

The 5' hypermutation boundary of kappa chains is independent of local and neighbouring sequences and related to the distance from the initiation of transcription.Semantic proximity Read ↗

The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron.Semantic proximity Read ↗

Defining the nucleic acid substrate for somatic hypermutation.Semantic proximity Read ↗

Insertion of 2 kb of bacteriophage DNA between an immunoglobulin promoter and leader exon stops somatic hypermutation in a kappa transgene.Semantic proximity Read ↗

Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J.Semantic proximity Read ↗

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