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Article

The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.

The Journal of biological chemistry - 26 Mar 2010

Featherstone Karen, Wood Andrew L, Bowen Adam J, Corcoran Anne E

Abstract excerpt

During immunoglobulin heavy chain (Igh) V(D)J recombination, D to J precedes V to DJ recombination in an ordered manner, controlled by differential chromatin accessibility of the V and DJ regions and essential for correct antibody assembly. However, with the exception of the intronic enhancer Emu...

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Share to Bone Marrow Cells
Share to Chromatin
Share to DNA, Intergenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Genes, Immunoglobulin Heavy Chain

Share to Immunoglobulin Heavy Chains

Share to Models, Immunological

Share to Oligonucleotides, Antisense

Source

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Identifiers

PMID: 20100833
DOI: 10.1074/jbc.M109.098251
PMCID: PMC2843181

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20100833-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.PMID 20100833Read ↗

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