Inferring gene expression from cell-free DNA fragmentation profiles.

doi:10.1038/s41587-022-01222-4

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Article

Inferring gene expression from cell-free DNA fragmentation profiles.

Nature biotechnology - 1 Apr 2022

Esfahani Mohammad Shahrokh, Hamilton Emily G, Mehrmohamadi Mahya, Nabet Barzin Y, Alig Stefan K, King Daniel A, Steen Chloé B, Macaulay Charles W, Schultz Andre, Nesselbush Monica C, Soo Joanne, Schroers-Martin Joseph G, Chen Binbin, Binkley Michael S, Stehr Henning, Chabon Jacob J, Sworder Brian J, Hui Angela B-Y, Frank Matthew J, Moding Everett J, Liu Chih Long, Newman Aaron M, Isbell James M, Rudin Charles M, Li Bob T, Kurtz David M, Diehn Maximilian, Alizadeh Ash A

Abstract excerpt

Profiling of circulating tumor DNA (ctDNA) in the bloodstream shows promise for noninvasive cancer detection. Chromatin fragmentation features have previously been explored to infer gene expression profiles from cell-free DNA (cfDNA), but current fragmentomic methods require high concentrations of tumor-derived DNA and provide limited resolution. Here we describe promoter fragmentation entropy as an epigenomic...

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Identifiers

PMID: 35361996
DOI: 10.1038/s41587-022-01222-4
PMCID: PMC9337986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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