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Cell type signatures in cell-free DNA fragmentation profiles reveal disease biology

12 Mar 2024

Abstract excerpt

Circulating cell-free DNA (cfDNA) fragments have characteristics that are specific to the cell types that release them. Current methods for cfDNA deconvolution typically use disease tailored marker selection in a limited number of bulk tissues or cell lines. Here, we utilize single cell transcriptome data as a comprehensive cellular reference set for disease-agnostic cfDNA cell-of-origin analysis. We correlate...

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PMID: 38472221
DOI: 10.1038/s41467-024-46435-0

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