Article

ChIP-seq of plasma cell-free nucleosomes identifies cell-of-origin gene expression programs

2019-05-15

Abstract excerpt

<h4>Abstract:</h4> Genomic DNA is packed by histone proteins that carry a multitude of post-translational modifications that reflect cellular transcriptional state. Cell-free DNA (cfDNA) is derived from fragmented chromatin in dying cells, and as such it retains the histones markings present in the cells of origin. Here, we pioneer chromatin immunoprecipitation followed by sequencing of cell-free nucleosomes (cfC...

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Literature Corpus work: 0eb9c4c0-6bd9-504f-80b8-901cd85a7df2
DOI: 10.1101/638643

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