Article

Cancer-like fragmentomic characteristics of somatic variants in cell-free DNA

2025-05-02

Abstract excerpt

Cell-free DNA (cfDNA) in plasma consists of short DNA fragments resulting from a non-random fragmentation process, with distinct “fragmentomic” characteristics that are related with their cellular origins. Despite the wealth of low-pass whole genome sequencing data from recent cancer liquid biopsy studies, somatic variants within this data have often been overlooked without detailed characterization. Here, we repo...

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Literature Corpus work: 8ddf6f5b-d2e3-550a-a182-da7731fd4c3f
DOI: 10.1101/2025.04.28.651130

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