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Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection

11 Oct 2019

Abstract excerpt

Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-invasive assays for assessing transcription factor activity are lacking. Here we develop and validate a minimally invasive method for assessing TF activity based on cell-free DNA sequencing and nucleosome footprint analysis. We analyze whole genome sequencing data for >1,000 cell-free DNA samples from cancer patients and...

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PMID: 31604930
DOI: 10.1038/s41467-019-12714-4

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