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Article

Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation

1 Dec 2015

Abstract excerpt

BACKGROUND: The assessment of cell-free circulating DNA fragments, also known as a "liquid biopsy" of the patient's plasma, is an important source for the discovery and subsequent non-invasive monitoring of cancer and other pathological conditions. Although the nucleosome-guided fragmentation patterns of cell-free DNA (cfDNA) have not yet been studied in detail, non-random representation of cfDNA sequencies may...

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PMID: 26693644
DOI: 10.1186/1471-2164-16-s13-s1

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