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Chromatin- and nucleosome-associated features in liquid biopsy: implications for cancer biomarker discovery

13 Mar 2024

Abstract excerpt

Cell-free DNA (cfDNA) from the bloodstream has been studied for cancer biomarker discovery, and chromatin-derived epigenetic features have come into the spotlight for their potential to expand clinical applications. Methylation, fragmentation, and nucleosome positioning patterns of cfDNA have previously been shown to reveal epigenomic and inferred transcriptomic information. More recently, histone modifications...

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PMID: 38478957
DOI: 10.1139/bcb-2024-0004

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