Article

Cell-free DNA Fragmentation Profiling at Transcription Start Sites Improves upon Cancer-Type-Specific Region Selection for Cancer Detection

2026-06-26

Abstract excerpt

<h4>Motivation</h4> Accurate discrimination between healthy individuals and patients with cancer using minimally invasive liquid biopsies could improve cancer diagnosis and monitoring. Circulating cell-free DNA (cfDNA) is a promising biomarker, since fragmentation patterns reflect chromatin organization and have been used to interrogate regulatory regions such as transcription start sites (TSSs). Classification a...

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Literature Corpus work: dcf599b3-eb9d-53df-bf0a-5b902a296845
DOI: 10.64898/2026.06.22.733692

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