Article

CRAG: <i>De novo</i> characterization of cell-free DNA fragmentation hotspots in plasma whole-genome sequencing

2020-07-16

Abstract excerpt

Non-random cell-free DNA fragmentation is a promising signature for cancer diagnosis. However, its aberration at the fine-scale in early-stage cancers is poorly understood. Here, we developed an approach to de novo characterize the cell-free DNA fragmentation hotspots from whole-genome sequencing. In healthy, hotspots are enriched in gene-regulatory elements, including open chromatin regions, promoters, hematopoi...

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Literature Corpus work: 0c68d630-3dd0-5ffc-87ae-94a0710a324f
DOI: 10.1101/2020.07.16.201350

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