Article

Integrated inference of cancer gene expression from cell-free plasma chromatin

2026-02-19

Abstract excerpt

<h4>ABSTRACT</h4> Gene expression is a defining determinant of tumor identity, behavior, and therapeutic response, yet remains challenging to measure noninvasively. Here, we introduce APEX (Associating Plasma Epigenomic features with eXpression), a framework for inferring expression from circulating cell-free chromatin. Trained on ∼270,000 gene–sample pairs from matched tumor RNA-seq and plasma cfChIP-seq across...

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Literature Corpus work: dfb4ee32-cbed-5640-89d8-33d20bc7169e
DOI: 10.64898/2026.02.18.706026

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