Article

A chromatin fiber model explains cell-free DNA fragmentation signatures of active regulatory elements

2025-11-07

Abstract excerpt

Circulating cell-free DNA (cfDNA) assays are being widely adopted in oncology and maternal-fetal medicine. Patterns of cfDNA fragmentation can provide useful information about gene regulation and expression in human disease from a blood draw. Here, we demonstrate that enhancer RNA expression – a marker of enhancer activity – can be inferred from local patterns of cfDNA fragmentation. We define a transcriptional ac...

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Literature Corpus work: 00c21058-32bc-5a65-b842-a39e8d45d483
DOI: 10.1101/2025.11.06.686988

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