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Parsimonious Clone Tree Integration in cancer

14 Mar 2022

Abstract excerpt

BACKGROUND: Every tumor is composed of heterogeneous clones, each corresponding to a distinct subpopulation of cells that accumulated different types of somatic mutations, ranging from single-nucleotide variants (SNVs) to copy-number aberrations (CNAs). As the analysis of this intra-tumor heterogeneity has important clinical applications, several computational methods have been introduced to identify clones from...

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PMID: 35282838
DOI: 10.1186/s13015-022-00209-9

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