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Article

Clonality inference in multiple tumor samples using phylogeny.

Bioinformatics (Oxford, England) - 1 May 2015

Malikic Salem, McPherson Andrew W, Donmez Nilgun, Sahinalp Cenk S

Abstract excerpt

MOTIVATION: Intra-tumor heterogeneity presents itself through the evolution of subclones during cancer progression. Although recent research suggests that this heterogeneity has clinical implications, in silico determination of the clonal subpopulations remains a challenge. RESULTS: We address this problem through a novel combinatorial method, named clonality inference in tumors using phylogeny (CITUP), that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25568283
DOI: 10.1093/bioinformatics/btv003

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