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Article

Reconstructing tumor evolutionary histories and clone trees in polynomial-time with SubMARine.

PLoS computational biology - 1 Jan 2021

Sundermann Linda K, Wintersinger Jeff, Rätsch Gunnar, Stoye Jens, Morris Quaid

Abstract excerpt

Tumors contain multiple subpopulations of genetically distinct cancer cells. Reconstructing their evolutionary history can improve our understanding of how cancers develop and respond to treatment. Subclonal reconstruction methods cluster mutations into groups that co-occur within the same subpopulations, estimate the frequency of cells belonging to each subpopulation, and infer the ancestral relationships among...

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PMID: 33465079
DOI: 10.1371/journal.pcbi.1008400
PMCID: PMC7845980

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