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Article

Phylogenetic Copy-Number Factorization of Multiple Tumor Samples

16 Apr 2018

Abstract excerpt

Cancer is an evolutionary process driven by somatic mutations. This process can be represented as a phylogenetic tree. Constructing such a phylogenetic tree from genome sequencing data is a challenging task due to the many types of mutations in cancer and the fact that nearly all cancer sequencing is of a bulk tumor, measuring a superposition of somatic mutations present in different cells. We study the problem...

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PMID: 29658782
DOI: 10.1089/cmb.2017.0253

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