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Sc-TUSV-Ext: Single-Cell Clonal Lineage Inference from Single Nucleotide Variants, Copy Number Alterations, and Structural Variants.

Journal of computational biology : a journal of computational molecular cell biology - 1 Aug 2025

Bristy Nishat Anjum, Fu Xuecong, Schwartz Russell

Abstract excerpt

Clonal lineage inference ("tumor phylogenetics") has become a crucial tool for making sense of somatic evolution processes that underlie cancer development and are increasingly recognized as part of normal tissue growth and aging. The inference of clonal lineage trees from single-cell sequence data offers particular promise for revealing processes of somatic evolution in unprecedented detail. However, most such...

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PMID: 40049606
DOI: 10.1089/cmb.2024.0613
PMCID: PMC12501414

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