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Canalization of the Polygenic Risk for Common Diseases and Traits in the UK Biobank Cohort.

Molecular biology and evolution - 11 Apr 2022

Nagpal Sini, Tandon Raghav, Gibson Greg

Abstract excerpt

Since organisms develop and thrive in the face of constant perturbations due to environmental and genetic variation, species may evolve resilient genetic architectures. We sought evidence for this process, known as canalization, through a comparison of the prevalence of phenotypes as a function of the polygenic score (PGS) across environments in the UK Biobank cohort study. Contrasting seven diseases and three...

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PMID: 35275999
DOI: 10.1093/molbev/msac053
PMCID: PMC9004416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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