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Article

Assessing Orthogonality in Gene-Environment Interaction Studies Using Polygenic Indices.

Behavior genetics - 1 Jan 2026

Slob Eric A W, Muslimova Dilnoza, Rietveld Cornelius A

Abstract excerpt

Gene-environment interaction (G×E) studies analyze how environmental conditions cushion or exacerbate differences in genetic endowments. A gene-environment correlation (rGE) between the polygenic index (PGI) and the environmental condition employed in these G×E studies could bias the estimation of the interaction effect. In this brief report, we discuss the limitations of the commonplace correlation-based test...

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Identifiers

PMID: 41507469
DOI: 10.1007/s10519-025-10248-8
PMCID: PMC12795928

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