Article

Distinct explanations underlie gene-environment interactions in the UK Biobank

2023-09-23

Abstract excerpt

The role of gene-environment (GxE) interaction in disease and complex trait architectures is widely hypothesized, but currently unknown. Here, we apply three statistical approaches to quantify and distinguish three different types of GxE interaction for a given trait and E variable. First, we detect locus-specific GxE interaction by testing for genetic correlation ( r g ) < 1 across E bins. Second, we detect genom...

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Literature Corpus work: 44928040-675e-5a73-8b8e-295a57aa0a86
DOI: 10.1101/2023.09.22.23295969

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