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Article

Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions.

Nature genetics - 1 Aug 2026

Nagpal Sini, Gibson Greg

Abstract excerpt

The generalizability of polygenic scores (PGS) remains a major hurdle in the pursuit of equitable genomic medicine. Differences in disease prevalence across groups, potentially including social strata, influence the relationship between PGS and risk. Here we quantified the magnitude of PGS-by-context (PGS×C) interactions for seven human diseases and pairs of 75 contexts in the UK Biobank (n = 408,801). Across...

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Identifiers

PMID: 42443528
DOI: 10.1038/s41588-026-02674-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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