Article

Dual exposure-by-polygenic score interactions highlight disparities across social groups in the proportion needed to benefit

2024-07-30

Abstract excerpt

The transferability of polygenic scores across population groups is a major concern with respect to the equitable clinical implementation of genomic medicine. Since genetic associations are identified relative to the population mean, inevitably differences in disease or trait prevalence among social strata influence the relationship between PGS and risk. Here we quantify the magnitude of PGS-by-Exposure (PGSxE) in...

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Literature Corpus work: a5d440eb-bae6-5d6e-8748-8aa3219843fd
DOI: 10.1101/2024.07.29.24311065

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