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Article

Distinct explanations underlie gene-environment interactions in the UK Biobank.

American journal of human genetics - 6 Mar 2025

Durvasula Arun, Price Alkes L

Abstract excerpt

The role of gene-environment (GxE) interaction in disease and complex trait architectures is widely hypothesized but currently unknown. Here, we apply three statistical approaches to quantify and distinguish three different types of GxE interaction for a given trait and environmental (E) variable. First, we detect locus-specific GxE interaction by testing for genetic correlation (rg) < 1 across E bins. Second, we...

Topics

Humans
Gene-Environment Interaction
United Kingdom
Biological Specimen Banks
Polymorphism, Single Nucleotide
Female
Male
Multifactorial Inheritance
Genome-Wide Association Study
Phenotype
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

Quantitative Trait, Heritable

UK Biobank

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Open in PubMed Open full text

Identifiers

PMID: 39965571
DOI: 10.1016/j.ajhg.2025.01.014
PMCID: PMC11947178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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