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Canalization and Robustness in Human Genetics and Disease.

Annual review of genetics - 23 Nov 2020

Gibson Greg, Lacek Kristine A

Abstract excerpt

Canalization refers to the evolution of populations such that the number of individuals who deviate from the optimum trait, or experience disease, is minimized. In the presence of rapid cultural, environmental, or genetic change, the reverse process of decanalization may contribute to observed increases in disease prevalence. This review starts by defining relevant concepts, drawing distinctions between the...

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PMID: 32867542
DOI: 10.1146/annurev-genet-022020-022327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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