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Article

Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent.

Human genomics - 20 Jul 2023

De Lillo Antonella, Wendt Frank R, Pathak Gita A, Polimanti Renato

Abstract excerpt

To investigate the polygenicity of complex traits in populations of East Asian (EAS) and European (EUR) descents, we leveraged genome-wide data from Biobank Japan, UK Biobank, and FinnGen cohorts. Specifically, we analyzed up to 215 outcomes related to 18 health domains, assessing their polygenic architecture via descriptive statistics, such as the proportion of susceptibility SNPs per trait (πc). While we did...

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Identifiers

PMID: 37475089
DOI: 10.1186/s40246-023-00514-3
PMCID: PMC10360343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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