Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming

1 Jan 2022

Abstract excerpt

BACKGROUND & AIMS: Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse models of the disease. Although the tumor cell-intrinsic effects of oncogenic Kras expression have been widely studied, its role in regulating the extensive pancreatic tumor microenvironment is less understood. METHODS: Using a genetically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Pancreatic and Hepatic Oncology Research
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35245687
DOI: 10.1016/j.jcmgh.2022.02.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast ReprogrammingPMID 35245687Read ↗

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogrammingSemantic proximity Read ↗

SMAD4 and KRAS Status Shapes Cancer Cell-Stromal Cross-Talk and Therapeutic Response in Pancreatic Cancer.Semantic proximity Read ↗

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancerSemantic proximity Read ↗

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic CancerSemantic proximity Read ↗

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.Semantic proximity Read ↗

Fibroblast Heterogeneity in the Pancreatic Tumor MicroenvironmentSemantic proximity Read ↗

Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation.Semantic proximity Read ↗

Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtypeSemantic proximity Read ↗

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.Semantic proximity Read ↗

Stromal biology of pancreatic cancerSemantic proximity Read ↗

Pancreatic Fibroblast Heterogeneity: From Development to CancerSemantic proximity Read ↗

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.