Article

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancer

2024-04-30

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) contains an extensive stroma that modulates response to therapy, contributing to the dismal prognosis associated with this cancer. Evidence suggests that the stromal composition of PDAC is shaped by mutations within malignant cells; however, most pre-clinical models of PDAC are driven by Kras G12D and mutant Trp53 and have not assessed the contribution...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd4f4996-4fa5-5b0e-b378-f3ae02e6783e
DOI: 10.1101/2024.04.28.591518

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SMAD4 and KRAS status shape malignant-stromal crosstalk in pancreatic cancerDOI 10.1101/2024.04.28.591518Read

SMAD4 and KRAS Status Shapes Cancer Cell-Stromal Cross-Talk and Therapeutic Response in Pancreatic Cancer.Semantic proximity Read

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogrammingSemantic proximity Read

Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation.Semantic proximity Read

Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer.Semantic proximity Read

Single-Cell Analysis Differentiates the Effects of p53 Mutation and p53 Loss on Cell Compositions of Oncogenic Kras-Driven Pancreatic Cancer.Semantic proximity Read

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.Semantic proximity Read

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolutionSemantic proximity Read

KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment.Semantic proximity Read

New insight into the role of SMAD4 mutation/deficiency in the prognosis and therapeutic resistance of pancreatic ductal adenocarcinomas.Semantic proximity Read

Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtypeSemantic proximity Read

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesisSemantic proximity Read

Myc instructs and maintains pancreatic adenocarcinoma phenotypeSemantic proximity Read